What is Spravato?

Spravato is a name-brand prescription nasal spray, that uses Esketamine, to help patients who are struggling with treatment-resistant depression. Esketamine has been approved for anesthetics and low dosage pain medication since the 1960’s, however, it was only recently approved as a treatment for depression. Spravato therapy is the first and only FDA approved NMDA receptor antagonist to help treat depression. Treatment resistant depression (TRD) is depression that has not improved after trying two or more different prescription antidepressants. Spravato requires treatment centers to have a certification in order to administer the nasal spray. Seattle Regenerative Medicine Center received their certification on May 1st, 2019, only two months after FDA approval in March.

Who can be treated with Spravato Therapy?

Patients that are eligible for treatment are patients who are suffering from treatment resistant depression, and have tried two or more prescription medications. This includes patients suffering from anxiety and bipolar disorder. If you are tired of feeling this way and ready to get back to your old self quickly, then Spravato could be the right treatment option for you.


How Does it Work?

Esketamine targets and binds the NMDA receptors in the brain. Which then increases the amount of glutamate between neurons. Glutamate works by activating connections to the AMPA receptor. This leads to the release of other molecules that help neurons communicate with each other, leading to synaptogenesis, which alters mood. Another possibility is that it reduces inflammation signals, which allows for easier communication in some areas of the brain. This is different than antidepressants, since they work by increasing neurotransmitters in the brain. Because antidepressants simply add chemicals to your brain, it takes much longer to feel a difference, than being treated with Spravato.

What are the Benefits?

Spravato is beneficial because it is fast-acting, and targets the source of treatment resistant depression. While antidepressants usually take about four to six weeks to become effective, Spravato takes effect within a couple of hours. Spravato targets TRD through the nasal spray treatments, while still allowing you to take your normal antidepressant medication.